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Effects Of Drugs In Fetus
Effects Of Drugs In Fetus

Observational Cohort Study of Pregnancy Outcome after First-Trimester Exposure to Fluoroquinolones

Fluoroquinolones are avoided during pregnancy due to developmental toxicity in animals. The aim of this study was to assess the fetal risk after intrauterine fluoroquinolone exposure. We performed an observational study of a prospectively ascertained cohort of pregnant women exposed to a fluoroquinolone during the first trimester. Pregnancy outcomes were compared to those of a cohort exposed to neither fluoroquinolones nor teratogenic or fetotoxic drugs.

This service is more advanced with JavaScript available, learn more at http: Archives of Toxicology. In Dutch-belted rabbits, pregnancy caused several-fold decrease of in vitro hepatic microsomal aminopyrine, benzphetamine, and hexobarbital biotransformations. In pregnant Sprague-Dawley rats, various kinds of expressing the in vitro rates of hexobarbital biotransformation per mg of microsomal protein, g of liver, g of body weight indicated unchanged or slightly elevated microsomal enzyme activity. In vivothe course of hexobarbital blood levels after i. Different ways of expressing in vitro rates of aniline biotransformation showed decreased or unchanged enzyme activity during pregnancy and in vivo experiments indicated that these changes did not affect aniline metabolism Nude Actress Org living rats.

UP TO , only a few cases of malformations in man have been attributed to drugs, notably aminopterin Thiersch, ; 1 and ; 2 Meltzer, ; 3 and Warkany et al, 4 , busulfan Diamond et al 5 , androgens and progestogens Wilkins, 6 , cortisone Bongiovanni and McPadden, 7 , quinine Grebe, , 8 Uhlig, ; 9 and Windorfer, 10 , insulin Wickes, 11 , and tolbutamide Larsson and Sterky, A causal relationship has been well established only for aminopterin and for the androgenic and gestagenic hormones. A few cases of cleft palate following high doses of cortisone administered in early pregnancy are suggestive of a causative effect in view of similar results in animal experiments. A connection between quinine intake for artificial abortion and malformations has been assumed in selected cases.

Jetzt anmelden Anonym bewerten. Anmelden Konto anlegen. Ohne aktives Javascript kann es zu Problemen bei der Darstellung kommen. Bitte aktivieren Sie deshalb Ihr Javascript. Startseite Bücher Gerald Briggs: Drugs in Pregnancy and Lactation, Gebunden. Gerald Briggs:

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A must own - This is the 11th edition of a core drug reference in the field of maternal health and a worthwhile contribution to the discipline. Put essential information at your fingertips — before you prescribe. The updated 11th edition of Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk lists more than 1, commonly prescribed drugs taken during pregnancy and lactation, with detailed monographs that provide the information you need on known or possible effects on the mother, embryo, fetus, and nursing infant. For the 11th edition, this bestselling reference has two new authors, both highly knowledgeable on the effects of drugs on the embryo-fetus and nursing infant: Craig V.

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Effects Of Drugs In Fetus

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After the use of moxifloxacin, a detailed fetal ultrasound examination should be Using observational cohort data for studying drug effects on pregnancy. In Dutch-belted rabbits, pregnancy caused several-fold decrease of in vitrohepatic microsomal aminopyrine, benzphetamine, and hexobarbital. For the 11th edition, this bestselling reference has two new authors, both highly knowledgeable on the effects of drugs on the embryo-fetus and nursing infant.
Effects Of Drugs In Fetus

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Drug Metabolism in the Human Fetus and Newborn Infant discussion of the recent concern about the possible teratogenic effect of diphenylhydantoin in man. Possibilities of drug addiction treatment during pregnancy . Substance use during pregnancy and its consequences for mother and child - Focus Cannabis. Background: In order to improve the safety for drugs in pregnancy and lactation, data on the clinical practice must be collected and validated.

A few cases of cleft palate following high doses of cortisone administered in early pregnancy are suggestive of a causative effect in view of similar results in. A review of the similarities between drug and steroid hydroxylase activity in liver of polar drug and steroid metabolites in the fetus and adverse effects of these.

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Effects Of Drugs In Fetus

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